Cross cohort oral microbiome meta-analysis identifies shared OPMD OSCC dysbiosis while machine learning exposes limits of OSCC classifier transportability
Hannah Shi, Marziyeh Shafizadeh, Lala Rukh, Iman Beheshti, Anil Menon, Anastasia Kelekis‐Cholakis, Vimi Sunil Mutalik, Prashen Chelikani, Saeid Ghavami
The paper identifies shared microbial dysbiosis in OPMD and OSCC across cohorts and evaluates the transportability of an OSCC classifier, finding limited diagnostic utility.
bioRxiv · Aug 28, 2026 · PreprintCancer Biology