Amir Barzegar Behrooz

Treatment-Resilient Lipid Remodeling Defines Temozolomide Resistance and Failure of Simvastatin Sensitization in Glioblastoma

This paper identifies treatment-resilient lipid remodeling in TMZ-resistant glioblastoma cells, showing that resistance is linked to coordinated changes in multiple lipid families rather than single species.

BCL2L13 attenuation links impaired mitophagy to epithelial plasticity and anoikis tolerance in lung adenocarcinoma

This study shows that BCL2L13 downregulation in NSCLC promotes metastasis by impairing mitophagy and enhancing epithelial plasticity and anoikis tolerance.

Exploratory Network Analysis of Oral Bacteria Taste Signaling Autophagy Crosstalk in Oral Squamous Cell Carcinoma and Multi-Target Ligand Design for the MAPK1 STAT3 mTOR Axis

The paper integrates systems biology and machine learning to analyze bacterial signaling networks in OSCC, identifies key nodes, and designs multi-target ligands for the MAPK1-STAT3-mTOR axis.

Autophagy Cholesterol Axis Remodeling Supports Malignant Progression and Chemoresistance in Glioma

This study shows that autophagy and cholesterol metabolism are remodeled in glioma progression and TMZ resistance, with impaired autophagy linked to reduced cholesterol synthesis and altered lipid profiles.

Hierarchical Machine Learning Uncovers Topological Signatures of Autophagy Regulation by Oral Bacteria in Oral Squamous Cell Carcinoma

The paper uses hierarchical machine learning to identify topological differences in autophagy networks between pathogenic and commensal oral bacteria in OSCC.

Sex and Region-Specific Disruption of Autophagy and Mitophagy in Alzheimer's Disease: Linking Cellular Dysfunction to Cognitive Decline

This study examines sex-specific differences in autophagy and mitophagy in Alzheimer's disease using mouse models and machine learning to predict cellular outcomes.

The 40 Hz flickering light restores synaptic plasticity and mitochondrial phenotype in experimental model of Alzheimer's disease

This study shows that 40 Hz flickering light improves cognition and mitochondrial function in a rat model of Alzheimer's disease.

BCL2L13 Influences Autophagy and Ceramide Metabolism without Affecting Temozolomide Resistance in Glioblastoma

This study identifies BCL2L13 as a regulator of autophagy and ceramide metabolism in glioblastoma, showing distinct effects on metabolic pathways in TMZ-resistant and sensitive cells.

Unlocking a New Path: An Autophagometer that Measures Flux Using a Non-Fluorescent Immunohistochemistry Method

This paper introduces a non-fluorescent immunohistochemistry method to measure autophagy flux, demonstrating its cost-effectiveness and applicability to clinical settings.

Assessing Autophagy Flux in Glioblastoma Temozolomide Resistant Cells

This study develops a method to measure autophagy flux in TMZ-resistant glioblastoma cells using imaging and biochemical assays, providing insights into chemoresistance mechanisms.