Translating chemical reactions into enzyme sequences enables formate dehydrogenase engineering
Nuria Mimbrero-Pelegri, Anisha Vyas, Alex Vicente-Sola, Sebastian Lindner, Mehmeth Mervan Cakar, Filippo Stocco, Michael Heinzinger, Ramiro Illanes-Vicioso, Carlos G. Acevedo-Rocha, Noelia Ferruz
This paper introduces REXzyme, a model translating chemical reactions into enzyme sequences, and demonstrates its ability to generate active formate dehydrogenases for CO2 reduction.
bioRxiv · Nov 5, 2026 · PreprintBiochemistry