Sebastian Lindner

This paper introduces REXzyme, a model translating chemical reactions into enzyme sequences, and demonstrates its ability to generate active formate dehydrogenases for CO2 reduction.

The paper identifies that air bubbles in water bottles can cause dehydration in mice, and proposes a coiled wire solution to prevent this.

An enzyme-specific conditional language model generates active carbonic anhydrases and lactate dehydrogenases to user specification, some under 40% identity to natural proteins, with no retraining.