Molecular BiologybioRxivPreprint
KMT2A modulates the epigenetic landscape of rDNA by facilitating the recruitment of histone lysine acetyltransferase PCAF to the rDNA locus.
Kaisar Ahmad Lone, Anita Choudhary, Ajay Kumar Mahato, Shweta Tyagi
This study shows KMT2A facilitates PCAF recruitment to rDNA, enhancing H3 acetylation and RNA Pol I transcription, with loss of KMT2A disrupting the pre-initiation complex at the rDNA promoter.