Author

Kaisar Ahmad Lone

Centre for DNA Fingerprinting and DiagnosticsORCID 0000-0001-9132-6476Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Shweta TyagiiD· 2 shared Ajay Kumar MahatoiD· 1 shared Amit Mahendra Karole· 1 shared Anita Choudhary· 1 shared Geethanjali Ravindran· 1 shared

Activity by Year

2024-2026 · peak 1/yr

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5 top collaborators · 6 mutual co-author links

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2 shared papersMolecular Biology

Shweta TyagiORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 3, 2026

KMT2A modulates the epigenetic landscape of rDNA by facilitating the recruitment of histone lysine acetyltransferase PCAF to the rDNA locus.

Kaisar Ahmad Lone, Anita Choudhary, Ajay Kumar Mahato, Shweta Tyagi

This study shows KMT2A facilitates PCAF recruitment to rDNA, enhancing H3 acetylation and RNA Pol I transcription, with loss of KMT2A disrupting the pre-initiation complex at the rDNA promoter.

DOI 10.64898/2026.09.02.747590

mouseChIP-seq

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Molecular BiologybioRxivPreprintNov 4, 2024

H3K4me3 methyltransferase KMT2F promotes pre-initiation complex formation by RNA Polymerase I to regulate ribosomal RNA transcription.

Kaisar Ahmad Lone, Amit Mahendra Karole, Geethanjali Ravindran, Shweta Tyagi

This study identifies KMT2F as the primary enzyme depositing H3K4me3 on rDNA and shows its role in promoting RNA Pol I pre-initiation complex formation for ribosomal RNA transcription.

DOI 10.1101/2024.11.04.621718

humanDNA methylation

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