PAF15-PCNA assembly exhaustion governs lagging strand replication and replisome integrity
Gita Chhetri, Sugith Babu Badugu, Narcis-Adrian Petriman, Mikkel Borlum Petersen, Aylin Seren Güller, Nora Fajri, Manon Coulée, Ganesha P. Pitchai, Jan Novotný, Frederik T. Larsen, Andreas Fønss Møller, Morten Frendø Ebbesen, Tina Ravnsborg, Anoop Kumar Yadav, Barath Balarasa, , Kumar Somyajit
The paper identifies PAF15-PCNA assembly as a rate-limiting factor for lagging strand replication and replisome integrity, showing its regulation by the S-phase checkpoint.
Nature · Jan 28, 2026Peer-reviewedBiochemistry