Lipid Nanoparticles for Spleen-Targeted RNA delivery
Kseniya Yu. Vlasova, Noorjahan Aibani, Mrinmoy Sanyal, Marco Herrera‐Barrera, Avisek Deyati, Essam Helmy, Pierrot Harvie, Seba Jumaa, Daniel Arriaza, Miao-Chih Tsai, Ravindra Majeti, William James Greenleaf, Anitha M. Thomas, Howard Y. Chang
This study develops lipid nanoparticles (LNPs) for spleen-targeted RNA delivery without altering charge, showing improved splenic accumulation and distinct transcriptomic effects compared to conventional LNPs.
bioRxiv · Apr 15, 2026 · PreprintBioengineering