Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment
Julia Kolb, Vasiliki Tsata, Nora John, Kyoohyun Kim, Conrad Möckel, Gonzalo Rosso, Veronika Kurbel, Asha Parmar, Gargi Sharma, Kristina Karandasheva, Shada Abuhattum, Olga Lyraki, Timon Beck, Paul Friedrich Müller, Raimund Schlüßler, , Daniel Wehner
The paper identifies small leucine-rich proteoglycans (SLRPs) as inhibitors of CNS regeneration by altering the structural and mechanical properties of the injury ECM.
Nature Communications · Oct 26, 2023Peer-reviewedNeuroscience