Barbara A. Steigenberger

The paper describes DarHTG, a bacterial phage defense system that ADP-ribosylates double-stranded DNA using a helicase co-toxin, and identifies two subclasses with distinct target bases.

This study shows that transmembrane domain interactions in integrin β1-subunit are essential for proper folding and surface expression, with mutations disrupting these interactions causing functional impairments and embryonic lethality.

This study identifies the molecular interaction between Scm FCS finger and Pcl Tudor domain as the basis for PRC1 and PRC2.1 association in Drosophila.

This study shows that different stress types cause distinct plasma proteomic and metabolic responses in humans, with physical stress having the strongest effect.

The paper uses spatial proteomics to show IDO1's tumor-suppressive role in ovarian cancer by linking it to tryptophan metabolism and stress response pathways.

The paper presents a cryo-EM structure of the EMC:Spf1 supercomplex, showing how it integrates TMD insertion and dislocation activities for membrane protein quality control.

This study shows that IL4i1 metabolites from immune cells suppress ferroptosis in neuroblastoma cells by scavenging free radicals and activating NRF2, promoting tumor survival.

The paper identifies tumor-inhibitory fibroblasts that produce fibronectin, which activates signaling pathways in neighboring cells to enhance immune response against early cancer.

This study shows that modulating collagen-binding integrins can reduce fibrosis by inhibiting fibroblast activation in both liver and lung models, with differing mechanisms depending on the tissue.

The paper identifies small leucine-rich proteoglycans (SLRPs) as inhibitors of CNS regeneration by altering the structural and mechanical properties of the injury ECM.