Molecular Complexes for Effective Inhibition of Tau Aggregation
Nalini Vijay Gorantla, Vinod Gokulkrishna Landge, Pramod Gudigenahally Nagaraju, Lisni P. Sunny, Anjhu Nair, Siba P. Midya, Poornima Priyadarshini C. G., Ekambaram Balaraman, Subashchandrabose Chinnathambi
The paper reports the design and testing of cobalt(II)-complexes that inhibit Tau aggregation and disaggregate preformed Tau fibrils, showing concentration-dependent effects and dual roles in prevention and disassembly.
bioRxiv · Jul 6, 2018 · PreprintNeuroscience