Subashchandrabose Chinnathambi

Neuronal lipid composition regulates distinct states of full-length tau assembly, mechanics and membrane interactions

This study shows how neuronal lipid composition affects full-length tau assembly, mechanics, and membrane interactions, revealing distinct states of tau-membrane interaction based on lipid type and tau assembly state.

LC3-associated endocytosis facilitates extracellular Tau aggregate internalization and degradation in microglia

This study shows that microglia use LC3-associated endocytosis (LANDO) to internalize and degrade extracellular Tau aggregates via lysosomal fusion.

Extracellular HDAC6 ZnF UBP domain enhances podosome-mediated neuronal migration

The paper investigates the role of HDAC6 ZnF UBP domain in enhancing podosome-mediated neuronal migration through actin remodelling.

Microglia undergoes chemokine receptor, CX3CR1-mediated internalization of extracellular Tau

This study investigates how CX3CR1 mediates Tau internalization by microglia and how AZD8797 modulates this interaction through molecular docking and dynamics simulations.

G-Protein coupled Purinergic P2Y12 receptor interacts and internalizes TauRD-mediated by membrane-associated actin cytoskeleton remodelling in microglia

This study shows that microglial P2Y12 receptor interacts with TauRD and mediates its internalization via actin remodeling, leading to microglial activation.

α- Linolenic acid modulates phagocytosis of extracellular Tau and induces microglial migration

This study shows that alpha-linolenic acid enhances microglial phagocytosis and degradation of extracellular Tau, reducing its spread in Alzheimer's disease.

Molecular Complexes for Effective Inhibition of Tau Aggregation

The paper reports the design and testing of cobalt(II)-complexes that inhibit Tau aggregation and disaggregate preformed Tau fibrils, showing concentration-dependent effects and dual roles in prevention and disassembly.