Single-molecule imaging of DNA repair and cytoplasmic rigidification in intracellular bacteria
Fiona A. Sargison, Nicolas Chérif Ducrot, Clara Kummerer, Claire Qu, Treasa B. O'Hagan, Elliott Haywood, Anju Kudhail, Amy N. Moores, Lindsay A. Baker, Stephan Uphoff
This study uses live-cell single-molecule tracking to measure DNA repair activity in intracellular E. coli and links it to metabolic and biophysical changes during macrophage infection.
bioRxiv · Sep 16, 2026 · PreprintMicrobiology