IL-1α drives a tumor-stroma-neutrophil axis through inflammatory fibroblast activation in head and neck cancer
Eva-Maria Hanschmann, Kirsten Bruderek, Francisca Hofmann-Vega, Mathias Schmidt, Bettina Budeus, Wibke Oberlies, Xiang Wei, Mathis Richter, Simon Lemm, Jagoda Agnieszka Szlachetko, Sarah Ryan, Almke Bader, Anke Daser, S Lang, Daniela Begandt, , Sven Brandau
This study identifies IL-1α as a driver of a tumor-stroma-neutrophil axis in HNSCC by inducing inflammatory fibroblast activation, enhancing neutrophil recruitment and infiltration.
bioRxiv · Jan 22, 2026 · PreprintCancer Biology