Graph theory for the analysis of micro-electrode array recordings of human brain slices - framework and benchmarking
Jonas Ort, Victoria Sofie Witzig, Aniella Bak, Jan Heckelmann, Ann-Kathrin Roeb, Hussam Hamou, Anke Höllig, Yvonne Weber, Hans Clusmann, Daniel Delev, Henner Koch
This paper benchmarks three graph construction methods for MEA recordings of human brain slices, showing method choice significantly affects network topology with effect sizes comparable to biological signals.
bioRxiv · Aug 18, 2026 · PreprintNeuroscience