Henner Koch

Graph theory for the analysis of micro-electrode array recordings of human brain slices - framework and benchmarking

This paper benchmarks three graph construction methods for MEA recordings of human brain slices, showing method choice significantly affects network topology with effect sizes comparable to biological signals.

Transport-Related Effects on Intrinsic and Synaptic Properties of Human Cortical Neurons: A Comparative Study

This study compares intrinsic and synaptic properties of human cortical neurons recorded on-site and off-site after a 30-40 minute transport, finding altered membrane potential, synaptic efficacy, and dendritic spine density.

Modeling AP2M1 Developmental and Epileptic Encephalopathy in Drosophila

This study models AP2M1-DEE in Drosophila, finding heat-sensitive paralysis, altered neuron morphology, and seizure resistance, suggesting developmental defects over synaptic dysfunction.

Nanoscale dendritic shaft constrictions shape synaptic integration in fine caliber principal neuron dendrites

The paper shows that dendrites have nanoscale constrictions that create electrical compartments, altering synaptic integration in neurons.

Flexible 3D kirigami probes for in vitro and in vivo neural applications

This paper introduces flexible 3D kirigami microelectrode arrays for in vitro and in vivo neural applications, showing spatially dependent electrophysiological activity patterns.

Comprehensive Analysis of Human Dendritic Spine Morphology and Density: Exploring Diversity of Human Dendritic Spines

This study analyzes human dendritic spine morphology and density using a unique dataset and deep learning, revealing sex and tissue-specific differences and changes over time in culture.

Morphotype-specific calcium signaling in human microglia

The paper analyzes Ca2+ signaling in human microglia and finds differences in signal properties across morphotypes.

Temporal Dynamics of Neocortical Development in Organotypic Mouse Cultures: A Comprehensive Analysis

This study tracks neocortical development in organotypic mouse brain slice cultures over five weeks, revealing stable network properties by two weeks and increased variability later, with implications for disease research.

Tau phosphorylated at serine 356 is associated with Alzheimer's disease pathology and can be lowered in mouse and human brain tissue using the NUAK inhibitor WZ4003

Long-term human organotypic brain slice cultures: a detailed protocol to provide a comprehensive framework for single-neuron and neuronal network investigations

This paper provides a detailed protocol for long-term human organotypic brain slice cultures, enabling extended electrophysiological studies and viral transduction.

Axonopathy and altered synaptic development in early hippocampal epileptogenesis of Dravet syndrome

This study uses single-cell RNA sequencing in a Dravet syndrome mouse model to identify early transcriptomic changes and axonopathy in interneurons during epileptogenesis.

Modulation of Giant Depolarizing Potentials (GDPs) in Human Large Basket Cells by Norepinephrine and Acetylcholine

This study identifies and characterizes giant depolarizing potentials (GDPs) in human neocortical neurons, showing their modulation by norepinephrine and acetylcholine.

Dravet variant SCN1AA1783V impairs interneuron firing predominantly by altered channel activation

This paper characterizes the functional impact of the SCN1AA1783V variant in Dravet syndrome by combining electrophysiology, computational modeling, and in vitro validation, showing impaired interneuron firing due to altered channel activation.

Human cerebrospinal fluid induce neuronal excitability changes in resected human neocortical and hippocampal brain slices

This study shows that human cerebrospinal fluid (hCSF) increases neuronal activity and network reconfiguration in human brain slices compared to artificial cerebrospinal fluid (aCSF).

PINK1 Regulates Dopamine and Lipids at Mitochondria to Maintain Synapses and Neuronal Function

This study identifies PINK1's role in regulating mitochondrial function, lipid metabolism, and dopamine homeostasis in dopaminergic neurons, showing that cholesterol depletion can reverse PINK1-related phenotypes.