A novel non-catalytic function of PA2803-encoded PcrP contributes to polymyxin B resistance in P. aeruginosa and redefines the functional role of the PA2803 subfamily.
Tarosha Salpadoru, Sharmily Khanam, Veniamin A. Borin, Maha Achour, Denise Oh, Mert Kanik, Prasadi C. Gallage, Anna A. Khanov, Mackenzie Hull, Spencer P. Pitre, Pratul K. Agarwal, Michael John Franklin, Marianna A. Patrauchan
This study identifies a novel non-catalytic function of PcrP, a PA2803 subfamily protein, which contributes to polymyxin B resistance in P. aeruginosa through protein interactions and Ca2+-dependent mechanisms.
bioRxiv · May 13, 2025 · PreprintMicrobiology