The NBSGW RIP-DTR Mouse: An Integrated Platform for Diabetes Induction, Human Immune Reconstitution and Transplantation Studies
Connie S. Chamberlain, Deep Kapadia, Ellen Abad Santos, Liupei Huang, Alexis M. Holm, Caterra M. Leavens, Ayesha Palwasha Khan, Katherine M Gorski, Colin C. Steck, Anna E. Mikat, Daniel M. Tremmel, Peter J. Chlebeck, Kayla Talerico, Esau J. Estrada, Brian E. McIntosh, , Jon S. Odorico
The paper introduces the NBSGW RIP-DTR mouse model, which enables controlled diabetes induction, human immune reconstitution, and islet transplantation without irradiation.
bioRxiv · Jul 29, 2026 · PreprintImmunology