Bleb formation induced by acidic mixing buffers improves liquid stability of mRNA-LNPs
Julian Grundler, Beata Chertok, Anoop Nilam, Anna Edmundson, Mason Song, Michael Newton, Matthew R. Scholfield, Adora M. Padilla, Nicole M. Payton
This paper shows that using acidic mixing buffers during mRNA-LNP formation increases liquid stability by reducing mRNA degradation and extending storage life.
bioRxiv · Mar 17, 2026 · PreprintBiochemistry