Decreased spliceosome fidelity inhibits mTOR signalling and promotes longevity via an intron retention event
Wenming Huang, Chun Kew, Stephanie Fernandes, Anna Loerhke, Lynn K. Han, Constantinos Demetriades, Adam Antebi
The paper identifies a splicing factor mutation that enhances longevity in C. elegans by causing intron retention and inhibiting mTOR signaling.
bioRxiv · Mar 7, 2022 · PreprintGenetics