Disruption of prepulse inhibition is associated with severity of compulsive behavior and nucleus accumbens dopamine system changes in Sapap3 knockout mice
Elizabeth E. Manning, Abigail Y. Wang, Linda M. Saikali, Anna S. Winner, Susanne E. Ahmari
This study examines the relationship between sensorimotor gating disruption, compulsive behavior, and dopamine receptor levels in Sapap3 knockout mice, finding a correlation between PPI disruption and severe compulsive grooming.
Scientific Reports · May 3, 2021Peer-reviewedNeuroscience