Susanne E. Ahmari

This study shows that stopping GLP-1RA treatment in mice with binge-like eating restores binge behavior and leads to weight gain beyond pre-treatment levels.

This study examines RNA expression in thalamic nuclei of OCD patients and controls, finding minimal differential expression despite previous findings in other brain regions.

This paper identifies the striatal indirect pathway as mediating hesitation in mice through cell-type specific electrophysiology and optogenetics.

This study investigates the roles of central striatum (CS) and anterior lateral motor area (ALM) in initiating and sustaining naturalistic grooming behavior using fiber photometry and optogenetic stimulation in mice.

The paper identifies indirect pathway-projecting spiny projection neurons as a driver of compulsive behavior in a mouse model and shows that reducing their activity alleviates compulsive grooming.

This study examines Sapap3 knockout mice in a platform mediated avoidance task, finding heightened threat bias and altered avoidance behavior compared to controls, suggesting mOFC dysfunction in OCD-related mechanisms.

This study examines neural activity in corticostriatal regions during binge-like eating in mice, finding reduced dorsolateral striatum activity in binge eaters compared to controls.

This study examines binge-like eating behavior in mice after intermittent palatable food exposure, finding that daily access leads to greater escalation and persistence compared to less frequent access.

The paper investigates LOFC activity during compulsive grooming and reversal learning in OCD models, finding distinct neural patterns that normalize with fluoxetine treatment.

This study examines the relationship between sensorimotor gating disruption, compulsive behavior, and dopamine receptor levels in Sapap3 knockout mice, finding a correlation between PPI disruption and severe compulsive grooming.

The paper identifies differentially expressed transcripts in OCD patients' striatum and OFC, showing enrichment for synapse-associated genes and changes in cell type fractions.