Elizabeth E. Manning

Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function

The paper shows that striatal neuroinflammation disrupts astrocyte function, leading to excessive goal-directed action control in rats.

Hyperactivity of indirect pathway-projecting spiny projection neurons drives compulsive behavior

The paper identifies indirect pathway-projecting spiny projection neurons as a driver of compulsive behavior in a mouse model and shows that reducing their activity alleviates compulsive grooming.

Sapap3 knockout mice show threat bias under conflict during platform mediated avoidance task: implications for obsessive compulsive disorder

This study examines Sapap3 knockout mice in a platform mediated avoidance task, finding heightened threat bias and altered avoidance behavior compared to controls, suggesting mOFC dysfunction in OCD-related mechanisms.

Optogenetic recruitment of hypothalamic corticotrophin-releasing-hormone (CRH) neurons reduces motivational drive

This study shows that optogenetic activation of hypothalamic CRH neurons increases stress-related behaviors and reduces sucrose motivation, suggesting a role for these neurons in motivational drive.

Optical Von-Frey method to determine nociceptive thresholds:a novel paradigm for preclinical pain assessment and analgesic screening

This study introduces an optical method to measure nociceptive thresholds in mice using photostimulation of TRPV1-expressing nociceptors, showing it can detect analgesic effects like morphine.

Independent and distinct patterns of abnormal lateral orbitofrontal cortex activity during compulsive grooming and reversal learning normalize after fluoxetine

The paper investigates LOFC activity during compulsive grooming and reversal learning in OCD models, finding distinct neural patterns that normalize with fluoxetine treatment.

Disruption of prepulse inhibition is associated with severity of compulsive behavior and nucleus accumbens dopamine system changes in Sapap3 knockout mice

This study examines the relationship between sensorimotor gating disruption, compulsive behavior, and dopamine receptor levels in Sapap3 knockout mice, finding a correlation between PPI disruption and severe compulsive grooming.

Neurons in the ventral striatopallidal complex modulate lateral hypothalamic orexin/hypocretin neuron activity: Implications for reward-seeking

This study investigates how ventral striatopallidal neurons modulate orexin/hypocretin neuron activity in response to food and metabolic states, revealing their role in reward-seeking behavior.