Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes
Christina Bebber, Emily Thomas, Zhiyi Chen, Jenny Stroh, Ariadne Androulidaki, Anna Schmitt, Michaela Hoehne, Lukas Stueker, Marcel Dammert, Fatma Parmaksiz, Cleidson de Padua Alves, Armin Khonsari, Filippo Beleggia, Martin Sos, Jan Riemer, , Silvia von Karstedt
The paper identifies ferroptosis sensitivity as a distinguishing feature of non-neuroendocrine SCLC subtypes and shows that combining ferroptosis induction with TRX pathway inhibition can selectively kill both non-NE and NE SCLC tumors.
Nature Communications · Apr 6, 2021Peer-reviewedCancer Biology