APR-246 and DNA polymerase theta inhibitor Novobiocinsynergize to eliminate TP53 mutant AML cells
Amos Tuval, Terra Lasho, Anna Spada, Mrinal M. Patnaik, Klas G Wiman
This study shows that combining APR-246 and Novobiocin synergistically kills TP53-mutant AML cells through p53-dependent and -independent mechanisms, with low toxicity.
bioRxiv · Nov 2, 2026 · PreprintCancer Biology