The T-cell niche tunes immune function through modulation of the cytoskeleton and TCR-antigen forces
Anna V. Kellner, Rae Hunter, Priscilla Do, Joel Eggert, Maya Jaffe, Delaney K. Geitgey, Miyoung Lee, Jamie A. G. Hamilton, Anthony J. Ross, Raira S. Ank, Rachel L. Bender, Rong Ma, Christopher C. Porter, Erik C. Dreaden, Byron B. Au-Yeung, , Khalid Salaita
This study shows that the adipocyte niche impairs T-cell function by modulating cytoskeletal dynamics and reducing TCR-antigen forces in both mice and human T-cells.
bioRxiv · Jan 31, 2024 · PreprintBioengineering