AXL mediates mast cell survival and resistance to tyrosine kinase inhibitors in mastocytosis
Kitsada Kangboonruang, Philippe Drabent, Fatlinda Maksut, Maxime Heintzé, Yves Lepelletier, Ludovic Lhermitte, Mélanie Féroul, Sébastien Letard, Caroline Kabore, Fabienne A. Brenet, C. Méni, Nicolas Cagnard, Vincent Bondet, Guillaume Lefèvre, Julie Bruneau, , Leïla Maouche-Chrétien
This study identifies AXL as a driver of mast cell survival and TKI resistance in mastocytosis and shows that dual KIT/AXL inhibition restores TKI sensitivity.
bioRxiv · Nov 3, 2025 · PreprintCancer Biology