Hexanucleotide repeat expansions in C9orf72 alter microglial responses and prevent a coordinated glial reaction in ALS
Pegah Masrori, Baukje Bijnens, Kristofer Davie, Suresh Kumar Poovathingal, Annet Storm, Nicole Hersmus, Laura Fumagalli, Ludo Van Den Bosch, Mark W. E. J. Fiers, Dietmar Rudolf Thal, Renzo Mancuso, Philip Van Damme
This study shows that C9orf72 hexanucleotide repeat expansions impair microglial function and disrupt glial communication in ALS, contributing to disease risk.
bioRxiv · Oct 26, 2022 · PreprintNeuroscience