Renzo Mancuso

Cross-protocol comparison of iPSC-microglia reveals hypofunction contributes to neuronal vulnerability and synaptic alterations in the MAPT-S305N model of frontotemporal dementia.

The paper compares two iPSC-microglia protocols to assess how the MAPT-S305N mutation affects microglial function and neuronal health in a frontotemporal dementia model.

The Alzheimers Disease Risk Genes MS4A4A And MS4A6A Cooperate to Negatively Regulate Trem2 and Microglia states

This study shows that MS4A4A and MS4A6A negatively regulate TREM2 and microglial function in Alzheimer's disease, suggesting they are potential drug targets.

Deep proteomic analysis of human microglia and model systems reveal fundamental biological differences of in vitro and ex vivo cells

The paper compares proteomic profiles of human and mouse microglia from different sources, revealing significant differences between in vitro and ex vivo cultures.

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer's disease

This study examines how APOE isoforms affect the transcriptomic and epigenomic features of human microglia in an Alzheimer's disease xenotransplantation model, identifying genotype-dependent differences.

A multi-pronged human microglia response to Alzheimer's disease Aβ pathology

This study identifies distinct microglial responses to amyloid-beta in AD using single-cell data, highlighting HLA-related and cytokine responses and their genetic modulation.

S100A8-enriched microglia populate the brain of tau-seeded and accelerated aging mice

The paper identifies S100A8-enriched microglia in tauopathy and accelerated aging mouse models, showing their presence in human AD and tauopathy biopsies.

Hexanucleotide repeat expansions in C9orf72 alter microglial responses and prevent a coordinated glial reaction in ALS

This study shows that C9orf72 hexanucleotide repeat expansions impair microglial function and disrupt glial communication in ALS, contributing to disease risk.

Spatial and temporal transcriptomics reveal microglia-astroglia crosstalk in the amyloid-β plaque cell niche of Alzheimer’s disease

The paper uses spatial transcriptomics and in situ sequencing to study gene networks in the amyloid-β plaque niche of AD, revealing microglia-astroglia interactions and myelination abnormalities.

Single nucleus sequencing fails to detect microglial activation

The paper shows that single nucleus RNA-Seq fails to detect microglial activation genes in human brain samples compared to single cell RNA-Seq.

Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology

The paper identifies AD risk genes that influence microglia response to amyloid-β but not TAU pathology in mouse models.

Stem cell derived human microglia transplanted in mouse brain to study genetic risk of Alzheimer's Disease

The paper demonstrates that human microglia derived from embryonic stem cells can engraft mouse brains and express Alzheimer's risk genes when exposed to Aβ, offering a new model to study genetic risk in AD.