Kristofer Davie

The paper identifies ST18 as a regulator of deep CA3 pyramidal neuron identity, showing its role in restricting a superficial-like program and shaping circuit integration through molecular and electrophysiological changes.

This study shows that Pink1 loss in Drosophila disrupts ensheathing glia, leading to dopaminergic synapse loss, and identifies vesicle trafficking factors as potential therapeutic targets.

The paper identifies unique transcriptional profiles of immature neurons in aged human hippocampus across healthy, Alzheimer's disease, and resilient conditions, linking them to homeostasis and cognitive resilience.

The paper identifies cis-acting genetic variants affecting enhancer function in Parkinson's Disease using multi-omics data and develops models to predict their regulatory impact.

The paper identifies a dynamic gene regulatory code in hippocampal granule cells that orchestrates synapse development through sequential regulation of transcription factors and target genes.

This study shows Lecanemab reduces amyloid pathology by activating microglia through Fc fragment engagement, enhancing phagocytosis and lysosomal degradation.

The paper identifies synaptic dysfunction in cholinergic projection neurons as an early indicator of Parkinsonism across multiple fly models and links it to olfactory dysfunction and dopaminergic decline.

The paper compares enhancer codes of cell types between mammalian neocortex and avian pallium using deep learning, finding higher divergence in excitatory neurons than other cell types.

Nova-ST is a cost-effective, high-resolution spatial transcriptomics platform that outperforms existing methods in sensitivity for mouse brain sections.

This study shows that C9orf72 hexanucleotide repeat expansions impair microglial function and disrupt glial communication in ALS, contributing to disease risk.

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

This study shows that slower mitochondrial development and lower metabolic activity in human cortical neurons compared to mice delay neuronal maturation, and stimulating mitochondria accelerates this process.

This study identifies impaired MCH-system function in AD models and patients, disrupting synaptic downscaling and neuronal activity stability.

The paper spatially integrates single-cell transcriptomics and epigenomics data to identify enhancers and gene regulatory relationships in Drosophila eye-antennal disc.

This study transplants human cortical neurons into mice to study their development and integration into mouse visual circuits, finding prolonged juvenile features and functional synaptic integration.

The paper identifies an intermediate cell state in melanoma through single-cell RNA-seq and ATAC-seq, revealing a gene regulatory network that governs phenotype switching and potential therapeutic targets.

The paper introduces cisTopic, a probabilistic framework for discovering cis-regulatory topics and cell states from single-cell epigenomics data, and validates its findings using RNA-seq co-expression networks and perturbation experiments.

This study creates a single-cell transcriptome catalogue of the Drosophila brain across its lifespan, revealing regulatory erosion and identifying novel neuronal states linked to ageing.