Computationally Guided Design of Two Novel Phosphodiesterase-4 Inhibitors for Treatment of Plaque Psoriasis
Annie Liu, Emma R. M. James, Justin B. Siegel
The paper designs two novel PDE4 inhibitors for plaque psoriasis with improved ADMET properties compared to Roflumilast using computational methods.
bioRxiv · Oct 23, 2026 · PreprintPharmacology & Toxicology