Single-cell RNA sequencing of peripheral blood defines two immunological subtypes of Sjögren's disease
G. Urbanski, Kimberly E. Taylor, Emily Flynn, Armita Norouzi, Catherine Chu, Brittany R. Davidson, Arnab Ghosh, Joanne Nititham, Ravi K. Patel, Annie W. Poon, Gabriela K. Fragiadakis, Alexis J. Combes, Walter L. Eckalbar, Lindsey A. Criswell, Chun Ye, Caroline H. Shiboski
The paper identifies two immunological subtypes of Sjögren's disease using single-cell RNA sequencing, highlighting distinct IFN-I signatures and transitional B cell characteristics.
bioRxiv · Feb 27, 2025 · PreprintGenomics