Walter L. Eckalbar

This paper identifies 23 candidate causal genes for critical COVID-19 by integrating severity-stratified, longitudinal cis-eQTL mapping with GWAS signals from 1,031 patients.

The paper identifies CD8+ T cells as key drivers of fibrosis in morphea-spectrum diseases through fibroblast IFN-γ signaling using spatial transcriptomics.

This study develops an iSCST framework for FFPE biopsies, identifying colitis-associated cell networks and VDZ response signatures in IBD patients.

The paper identifies key regulatory elements in bat limb development by comparing bat and mouse genomic datasets and swapping enhancer sequences to observe phenotypic changes.

This study identifies meningeal regulatory T cells (mTregs) expressing enkephalin that modulate mechanical pain sensitivity in female mice via a sex hormone-dependent opioid receptor mechanism.

The paper identifies two immunological subtypes of Sjögren's disease using single-cell RNA sequencing, highlighting distinct IFN-I signatures and transitional B cell characteristics.

The paper identifies a multi-omics recovery factor predictive of long COVID using data from the IMPACC study, showing it can predict LC risk early after infection.

This study identifies immune subtypes in hospitalized COVID-19 patients linked to clinical outcomes and long COVID risk through longitudinal multi-omics analysis.

This study investigates viral reactivation in COVID-19 patients, finding associations between reactivation of specific virus families and clinical outcomes, including mortality and PASC symptoms.

This study identifies altered monocyte subsets and suppressed interferon signaling in T2DM mice, contributing to worsened stroke outcomes through immunosuppression and inflammation.

The paper identifies molecular and structural changes in aging human lungs that contribute to fibrosis and impair lung function.

This study identifies AIS-associated genes and regulatory elements through RNA-seq and ChIP-seq in human and mouse tissues, revealing pathways involved in chondrogenesis and connective tissue maintenance.

The paper tests gene expression prediction models' performance across populations and finds poor generalizability to African Americans compared to European Americans.

The paper presents a high-resolution chromosome-assigned genome of the Komodo dragon, identifying adaptations in cardiovascular, muscular, and chemosensory systems through comparative genomics.

The paper maps genomic and epigenomic features of leptin-responsive hypothalamic neurons and identifies regulatory elements overlapping obesity-associated SNPs.

This study identifies pharmacogenetic variants associated with albuterol bronchodilator response in minority children with asthma using whole genome sequencing.

This study identifies antibiotic-induced changes in gene expression and regulation in HepG2 cells using RNA-seq and ChIP-seq.