Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: Implications for the involvement of pirin
Bardees M. Foda, Annika E. Baker, Łukasz Joachimiak, Marzena Mazur, Richard R. Neubig
This study shows that CCG-257081 overcomes melanoma resistance by inducing apoptosis and inhibiting the Rho/MRTF pathway, with pirin playing a role in this process.
Frontiers in Pharmacology · Jan 23, 2025Peer-reviewedPharmacology & Toxicology