The promoter mutation paucity as part of the dark matter of the cancer genome
Nicholas Allen Baclig Abad, Irina Glas, Chen Hong, Annika Small, Yoann Pageaud, Ana Rita R. Maia, Dieter Weichenhan, Christoph Plass, Barbara Hutter, Benedikt Brors, Cindy Körner, Lars Feuerbach
The paper identifies previously overlooked activating promoter mutations in cancer using a computational workflow applied to the PCAWG dataset, validating several candidates through luciferase assays.
bioRxiv · Jun 3, 2024 · PreprintBioinformatics