Dieter Weichenhan

GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer

This study identifies GLYATL1 as a mediator of endocrine resistance in luminal breast cancer by promoting metabolic and epigenetic changes that counteract estrogen deprivation.

Pipeline Olympics: continuable benchmarking of computational workflows for DNA methylation sequencing data against an experimental gold-standard

The paper benchmarks DNA methylation sequencing workflows against an experimental gold-standard, identifying superior workflows and developing a sustainable benchmarking platform.

Single-cell chromatin landscape and DNA methylation patterns reveal shared molecular programs in human tumor and non-tumor tissue CCR8+ Treg cells

The paper compares CCR8+ Treg cells in tumor and tumor-free tissues using chromatin accessibility and DNA methylation, finding high similarity suggesting tumor microenvironment activation of tissue Treg cells.

Pyjacker identifies enhancer hijacking events in acute myeloid leukemia including MNX1 activation via deletion 7q

Pyjacker detects enhancer hijacking in AML, identifying MNX1 activation via 7q deletion as a novel oncogenic mechanism.

The promoter mutation paucity as part of the dark matter of the cancer genome

The paper identifies previously overlooked activating promoter mutations in cancer using a computational workflow applied to the PCAWG dataset, validating several candidates through luciferase assays.

Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function

The paper identifies sequence preferences of TET enzymes that target DNA demethylation to bHLH and bZIP transcription factor binding sites.

Endothelial Dnmt3a controls placenta vascularization and function to support fetal growth

This study shows that Dnmt3a regulates placental vascularization and fetal growth by controlling DNA methylation in endothelial cells, identifying it as a key factor in placental function.

AmpliconDesign - An interactive web server for the design of high-throughput targeted DNA methylation assays

AmpliconDesign provides a web server for designing high-throughput targeted DNA methylation assays, improving primer design and analysis workflows for epigenetic studies.

DNA methylation signatures of a large cohort monozygotic twins clinically discordant for multiple sclerosis

The paper identifies DNA methylation differences in monozygotic twins discordant for multiple sclerosis, highlighting treatment effects and genetic confounders.

Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo

This study examines the dynamics of the cardiac myocyte epigenome during development and in chronic heart failure, revealing distinct epigenetic programs in health and disease.