The GLP-1R Agonist Semaglutide Reduces Motivated Running and Alters Dopamine Dynamics in the Nucleus Accumbens
Ethan P. Foscue, Richard Trinko, Jaysen Lara Jiménez, Edward Kong, Summer L. Thompson, Keira Stankewich, Anouk M. Corstens, Mireille J. M. Serlie, Jane R. Taylor, Ralph Dileone
This study shows that semaglutide reduces voluntary running and alters dopamine dynamics in the nucleus accumbens of mice, independent of food intake suppression.
bioRxiv · Oct 8, 2025 · PreprintNeuroscience