A Kinetochore-Associated Proteasome Pool Drives a Second Pathway of Cohesin Removal during Meiosis
Anshul Mishra, Rory J. Butler, Lori B. Koch, Christos Spanos, Aaron F. Severson, Adèle L. Marston, G. Valentin Börner
This study identifies a proteasome function that drives centromeric cohesin removal during meiosis II independently of separase activation, revealing a dual role for the proteasome in chromosome segregation.
bioRxiv · Aug 22, 2026 · PreprintGenetics