Constitutive Androstane Receptor induces Ribonucleotide Reductase-M2 expression and maintains hepatocyte ploidy in mice
Anjana Asokakumar, Bhoomika Mathur, Sandip Chorghade, Anthony Chau, Bea Cronologia, Frances Alencastro, Linda Wheeler, Christopher K. Mathews, David D. Moore, Andrew W. Duncan, Sayeepriyadarshini Anakk
This study shows that CAR maintains hepatocyte ploidy by inducing RRM2 expression, which supports DNA synthesis and tetraploid hepatocyte formation in mice.
bioRxiv · Apr 29, 2025 · PreprintCell Biology