David D. Moore

Nutrient-Sensing Nuclear Receptor PPARα Controls Liver Proteostasis

This study identifies PPARα as a regulator of liver proteostasis, showing it suppresses protein synthesis and secretion while enhancing proteasome activity and degradation.

Constitutive Androstane Receptor induces Ribonucleotide Reductase-M2 expression and maintains hepatocyte ploidy in mice

This study shows that CAR maintains hepatocyte ploidy by inducing RRM2 expression, which supports DNA synthesis and tetraploid hepatocyte formation in mice.

Oleic acid triggers hippocampal neurogenesis by binding to TLX/NR2E1

This study identifies oleic acid as a ligand for TLX/NR2E1 that promotes hippocampal neurogenesis by converting TLX from a repressor to an activator of cell cycle and neurogenesis genes.

Ubc9 deletion in adipocytes causes lipoatrophy in mice

This study shows that deleting Ubc9 in adipocytes causes lipoatrophy and metabolic issues in mice by disrupting adipose tissue expansion and function.