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Anthony Nolan

Imperial College London

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Synthetic Biology· 1

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Andrew M. ScharenbergiD· 1 shared Barry L. StoddardiD· 1 shared Raymond J. MonnatiD· 1 shared

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Andrew M. ScharenbergORCID

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Synthetic BiologybioRxivPreprintNov 27, 2016

Retargeting: an unrecognized consideration in endonuclease-based gene drive biology

Andrew M. Scharenberg, Barry L. Stoddard, Raymond J. Monnat, Anthony Nolan

The paper examines how mutations during transcription and genome replication can affect HR-mediated gene drive systems based on different nuclease platforms, highlighting the risk of retargeting and the need for risk assessment.

5 citations

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