Down- to up-state transition is the default pathway in TREK K2P channel activation and does not involve a lipid occluded pore
Marianne A. Musinszki, Chun Kei Lam, Edward Mendez-Otalvaro, Friederike Schulz, Elena B. Riel, Anthony Ogwo, Kristin Rathje, Lea C. Neelsen, Bert L. de Groot, Marcus Schewe, Thomas Baukrowitz
The paper identifies the down-to-up state transition as the primary activation pathway for TREK K2P channels, showing it does not involve lipid occlusion of the pore.
bioRxiv · May 11, 2026 · PreprintPhysiology