PhysiologybioRxivPreprint
Down- to up-state transition is the default pathway in TREK K2P channel activation and does not involve a lipid occluded pore
Marianne A. Musinszki, Chun Kei Lam, Edward Mendez-Otalvaro…·Thomas Baukrowitz
The paper identifies the down-to-up state transition as the primary activation pathway for TREK K2P channels, showing it does not involve lipid occlusion of the pore.
DOI 10.64898/2026.05.07.723243