Selective killing of plasma cell clones using splice-switching oligonucleotides targeting immunoglobulin variable exons.
Jean-Marie Lambert, Antoine Praité, Marion Contini, Mohamad Omar Ashi, Anne Marchalot, Soazig Le Pennec, Christophe Sirac, Sandy Al Hayek, Laurent Delpy
This study shows that splice-switching ASOs targeting V exons in myeloma cells induce selective plasma cell clone death via ER stress and apoptosis.
bioRxiv · Aug 30, 2024 · PreprintImmunology