Cholecystokinin input from the anterior cingulate cortex to the lateral periaqueductal gray mediates nocebo pain behavior in mice
Sandra J. Poulson, Aleksandrina Skvortsova, Fatama Tuz Zahra, Damien C. Boorman, Seyed Asaad Karimi, Lisiê Valéria Paz, Wanning Cui, Antonietta Mandatori, Jacob Burek, Zahra Siddiqi, Maryam I. Fazili, Shivani R Gami, Oakley B. Morgan, Mélanie Di Maria, Anton Dinh, , Loren J. Martin
The paper identifies a shared neural circuit involving CCK projections from the anterior cingulate cortex to the lateral periaqueductal gray that mediates nocebo pain behavior in mice.
Nature Communications · May 20, 2026Peer-reviewedNeuroscience