Jeffrey S. Mogil

The paper identifies a shared neural circuit involving CCK projections from the anterior cingulate cortex to the lateral periaqueductal gray that mediates nocebo pain behavior in mice.

This study shows that translational control in spinal cord neurons, particularly in inhibitory and PV+ interneurons, significantly influences gene expression and pain hypersensitivity during the chronic phase of neuropathic pain.

The paper identifies a paradoxical inflammation state in FM neutrophils that are unresponsive to LPS, linked to NF-κB suppression, and suggests bryostatin as a potential therapeutic target.

This study shows that nerve injury causes long-term systemic inflammation and pain hypersensitivity, with sex-dependent differences in immune and molecular responses.

This study shows that gut microbiota from fibromyalgia patients causes pain in mice, and transferring healthy microbiota alleviates symptoms in humans.

This study identifies genetic risk factors for chronic post-surgical pain through GWAS across five surgery types, finding immune-related genes contribute significantly to heritability.

The paper develops PainFace, a deep learning platform for automated mouse grimace scoring, showing it outperforms humans in speed and data generation, and identifies pain-related facial expressions.

This study investigates sex-based differences in endogenous opioid engagement during contextual control of pain tolerance and expectation in mice.

This study uses single-cell RNA sequencing to analyze spinal cord microglia responses to nerve injury, identifying sex- and time-specific changes and a role for ApoE in neuropathic pain.