Structural basis of substrate transport and drug recognition by the human thiamine transporter SLC19A3
Florian Gabriel, Lea Spriestersbach, Antonia Fuhrmann, Katharina E. J. Jungnickel, Siavash Mostafavi, Els Pardon, Jan Steyaert, Christian Löw
This study determines the cryo-EM structures of the human thiamine transporter SLC19A3 in complex with ligands, revealing its transport mechanism and drug interactions.
bioRxiv · Mar 11, 2024 · PreprintBiochemistry