TRF1 poly(ADP-ribosyl)ation by PARP1 allows proper telomere replication through helicase recruitment in non-ALT cells
C. Maresca, Angela Dello Stritto, C. D’Angelo, Eleonora Petti, Eleonora Vertecchi, Luca Pompili, Francesco Berardinelli, Antonella Sgura, Antonio Antoccia, Grazia Graziani, Annamaria Biroccio, Erica Salvati
This study shows PARP1 PARylates TRF1 to recruit helicases during telomere replication, preventing DNA damage in non-ALT cells.
bioRxiv · Oct 27, 2021 · PreprintMolecular Biology