Reconstitution of lipid nanoparticle-mediated siRNA transfer across endosomal membrane mimics
Alice Spadea, Anupam Singh, Lisa Redlingshoefer, Simona Sorrentino, Yannis Kalaidzidis, Marino Zerial
This study reconstitutes lipid nanoparticle-mediated siRNA transfer across endosomal membranes using GUVs, showing siRNA can translocate without membrane rupture or pH gradient loss.
bioRxiv · Nov 3, 2026 · PreprintCell Biology