Anupam Singh

This paper identifies separate metal-binding sites in Pol γ that regulate its DNA synthesis and strand displacement activities, revealing structural and biochemical mechanisms for mitochondrial DNA replication.

This study develops a high-resolution assay to show that the replisome, composed of helicase and DNA polymerase, is a powerful torsional motor that regulates DNA replication stalling and reactivation.

This study investigates how DNA polymerase interacts with the replication fork under stress and finds that prolonged stress inactivates replication and locks the fork, which is reversible only by helicase.

The paper shows that GroEL/ES buffers entropic traps in protein folding pathways introduced by mutations, which are rescued by the chaperonin, while it can also edit non-native contacts but is not utilized in vivo.